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"The prospective of conolidine as an alternative pain management solution is important, particularly in the context on the opioid disaster."In knee pain, nerves within the joint could become sensitized and have a heightened perception of pain. The results of conolidine within the opioid scavenger receptor can indirectly desensitize these nerves.Suc

Importantly, these receptors have been located to have already been activated by a variety of endogenous opioids in a concentration much like that observed for activation and signaling of classical opiate receptors. In turn, these receptors were located to own scavenging action, binding to and reducing endogenous levels of opiates readily available

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